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- Relation of Absolute or Relative Adiposity to Insulin Resistance, Retinol Binding Protein-4, Leptin, and Adiponectin in Type 2 Diabetes
- You Lim Kim, Tae Kyun Kim, Eun Sun Cheong, Dong Geum Shin, Gyu Sik Choi, Jihye Jung, Kyung-Ah Han, Kyung Wan Min
- Diabetes Metab J. 2012;36(6):415-421. Published online December 12, 2012
- DOI: https://doi.org/10.4093/dmj.2012.36.6.415
- 3,910 View
- 30 Download
- 11 Crossref
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Abstract
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PubReader Background Central fat mass (CFM) correlates with insulin resistance and increases the risk of type 2 diabetes and cardiovascular complications; however, peripheral fat mass (PFM) is associated with insulin sensitivity. The aim of this study was to investigate the relation of absolute and relative regional adiposity to insulin resistance index and adipokines in type 2 diabetes.
Methods Total of 83 overweighted-Korean women with type 2 diabetes were enrolled, and rate constants for plasma glucose disappearance (KITT) and serum adipokines, such as retinol binding protein-4 (RBP4), leptin, and adiponectin, were measured. Using dual X-ray absorptiometry, trunk fat mass (in kilograms) was defined as CFM, sum of fat mass on the lower extremities (in kilograms) as PFM, and sum of CFM and PFM as total fat mass (TFM). PFM/TFM ratio, CFM/TFM ratio, and PFM/CFM ratio were defined as relative adiposity.
Results Median age was 55.9 years, mean body mass index 27.2 kg/m2, and mean HbA1c level 7.12±0.84%. KITT was positively associated with PMF/TFM ratio, PMF/CFM ratio, and negatively with CFM/TFM ratio, but was not associated with TFM, PFM, or CFM. RBP4 levels also had a significant relationship with PMF/TFM ratio and PMF/CFM ratio. Adiponectin, leptin, and apolipoprotein A levels were related to absolute adiposity, while only adiponectin to relative adiposity. In correlation analysis, KITT in type 2 diabetes was positively related with HbA1c, fasting glucose, RBP4, and free fatty acid.
Conclusion These results suggest that increased relative amount of peripheral fat mass may aggravate insulin resistance in type 2 diabetes.
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Citations
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- Retinol-binding protein-4 and nonalcoholic fatty liver disease
Hangkai Huang, Chengfu Xu
Chinese Medical Journal.2022; 135(10): 1182. CrossRef - MANF in POMC Neurons Promotes Brown Adipose Tissue Thermogenesis and Protects Against Diet-Induced Obesity
Qin Tang, Qinhui Liu, Jiahui Li, Jiamin Yan, Xiandan Jing, Jinhang Zhang, Yan Xia, Ying Xu, Yanping Li, Jinhan He
Diabetes.2022; 71(11): 2344. CrossRef - The relation between body fat distribution, plasma concentrations of adipokines and the metabolic syndrome in patients with clinically manifest vascular disease
Ilse M Schrover, Yolanda van der Graaf, Wilko Spiering, Frank LJ Visseren
European Journal of Preventive Cardiology.2018; 25(14): 1548. CrossRef - Visceral Fat Mass Has Stronger Associations with Diabetes and Prediabetes than Other Anthropometric Obesity Indicators among Korean Adults
Suk Hwa Jung, Kyoung Hwa Ha, Dae Jung Kim
Yonsei Medical Journal.2016; 57(3): 674. CrossRef - Adipokines, cytokines and body fat stores in hepatitis C virus liver steatosis
Emilio González-Reimers
World Journal of Hepatology.2016; 8(1): 74. CrossRef - The effect of resveratrol on the expression of AdipoR1 in kidneys of diabetic nephropathy
Hongfei Ji, Lina Wu, Xiaokun Ma, Xiaojun Ma, Guijun Qin
Molecular Biology Reports.2014; 41(4): 2151. CrossRef - Retinol-binding protein 4 and insulin resistance are related to body fat in primary and secondary schoolchildren: the Ouro Preto study
Ana Paula Pereira Castro, Ana Paula Carlos Cândido, Roney Luiz de Carvalho Nicolato, Ivo Santana Caldas, George Luiz Lins Machado-Coelho
European Journal of Nutrition.2014; 53(2): 433. CrossRef - The Effects of Marathon Running on Retinol Binding Protein 4 and C-reactive Protein Levels in Healthy Middle-aged Korean Men
Jisuk Chae, Sungmin Kim, Junga Lee, Justin Y. Jeon
The Korean Journal of Obesity.2014; 23(3): 203. CrossRef - Modeling metabolic homeostasis and nutrient sensing in Drosophila: implications for aging and metabolic diseases
Edward Owusu-Ansah, Norbert Perrimon
Disease Models & Mechanisms.2014; 7(3): 343. CrossRef - Beneficial Effects of Fresh and Fermented Kimchi in Prediabetic Individuals
So-Yeon An, Min Suk Lee, Ja Young Jeon, Eun Suk Ha, Tae Ho Kim, Ja Young Yoon, Chang-Ok Ok, Hye-Kyoung Lee, Won-Sun Hwang, Sun Jung Choe, Seung Jin Han, Hae Jin Kim, Dae Jung Kim, Kwan-Woo Lee
Annals of Nutrition and Metabolism.2013; 63(1-2): 111. CrossRef - Regional Adiposity, Adipokines, and Insulin Resistance in Type 2 Diabetes
Jee-Young Oh
Diabetes & Metabolism Journal.2012; 36(6): 412. CrossRef
- Retinol-binding protein-4 and nonalcoholic fatty liver disease
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